Visit the HUJI website Publications of Prof. Daphne Atlas The Atlas Lab Research in the Atlas Lab About Prof. Daphne Atlas Back to Homepage
The Links

List of Publications


Years of Publication
For a comprehensive list of all publications found on the PubMed, click here





Publications - 2004                                                         Back to Top


117. Cohen R. and Atlas, D. R-type voltage-gated ca(2+) channel interacts with synaptic proteins and recruits synaptotagmin to the plasma membrane of xenopus oocytes. Neuroscience 128(4), 831-41 (2004). PDF
116. Offen, D., Gilgun-Sherki, Y., Barhum, Y., Benhar, M., Grinberg, L., Reich, R., Melamed, E. and Atlas, D. A low molecular weight copper chelator crosses the blood-brain barrier and attenuates Experimental Autoimmune Encephalomyelitis . J Neurochem. 89(5), 1241-51 (2004). PDF

Publications - 2003                                                         Back to Top


114. Arien, H., Wiser, O., Arkin, I.T., Leonov, H. & Atlas, D. Syntaxin 1A modulates the voltage-gated L-type calcium channel (Ca(v)1.2) in a cooperative manner. J Biol Chem 278, 29231-9 (2003). PDF
115. Cohen, R., Elferink, L.A. & Atlas, D. The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type). J Biol Chem 278, 9258-66 (2003). PDF

Publications - 2002                                                         Back to Top


113. Wiser, O., Cohen, R. & Atlas, D. Ionic dependence of Ca2+ channel modulation by syntaxin 1A. Proc Natl Acad Sci U S A 99, 3968-73 (2002). PDF

Publications - 2001                                                         Back to Top


109. Atlas, D. Functional and physical coupling of voltage-sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism. J Neurochem 77, 972-85 (2001). PDF
110. Atlas, D., Wiser, O. & Trus, M. The voltage-gated Ca2+ channel is the Ca2+ sensor of fast neurotransmitter release. Cell Mol Neurobiol 21, 717-31 (2001). PubMed
111. Barg, S. et al. Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. Biophys J 81, 3308-23 (2001). PDF
112. Trus, M., Wiser, O., Goodnough, M.C. & Atlas, D. The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channels. Neuroscience 104, 599-607 (2001). PDF

Publications - 1999                                                         Back to Top


107. Benatar, M. et al. Antibodies from ALS patients inhibit dopamine release mediated by L-type calcium channels. Neurology 52, 1520-1 (1999). PDF
108. Wiser, O. et al. The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery. Proc Natl Acad Sci U S A 96, 248-53 (1999). PDF

Publications - 1998                                                         Back to Top


105. Offen, D. et al. Antibodies from ALS patients inhibit dopamine release mediated by L-type calcium channels. Neurology 51, 1100-3 (1998). PubMed
106. Tobi, D., Wiser, O., Trus, M. & Atlas, D. N-type voltage-sensitive calcium channel interacts with syntaxin, synaptotagmin and SNAP-25 in a multiprotein complex. Receptors Channels 6, 89-98 (1998). PubMed

Publications - 1997                                                         Back to Top


103. Chan, S.L., Atlas, D., James, R.F. & Morgan, N.G. The effect of the putative endogenous imidazoline receptor ligand, clonidine-displacing substance, on insulin secretion from rat and human islets of Langerhans. Br J Pharmacol 120, 926-32 (1997). PDF
104. Wiser, O., Tobi, D., Trus, M. & Atlas, D. Synaptotagmin restores kinetic properties of a syntaxin-associated N-type voltage sensitive calcium channel. FEBS Lett 404, 203-7 (1997). PubMed

Publications - 1996                                                         Back to Top


100. Djaldetti, R., Atlas, D. & Melamed, E. Effect of subcutaneous administration of levodopa ethyl ester, a soluble prodrug of levodopa, on dopamine metabolism in rodent striatum: implication for treatment of Parkinson's disease. Clin Neuropharmacol 19, 65-71 (1996). PubMed
101. Wiser, O., Bennett, M.K. & Atlas, D. Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels. Embo J 15, 4100-10 (1996). PubMed
102. Wiser, O. et al. The alpha 2/delta subunit of voltage sensitive Ca2+ channels is a single transmembrane extracellular protein which is involved in regulated secretion. FEBS Lett 379, 15-20 (1996). PDF

Publications - 1995                                                         Back to Top


98. Atlas, D. Molecular and physiological properties of clonidine-displacing substance. Ann N Y Acad Sci 763, 314-24 (1995). PubMed
99. Gilad, B., Shenkar, N., Halevi, S., Trus, M. & Atlas, D. Identification of the alternative spliced form of the alpha 2/delta subunit of voltage sensitive Ca2+ channels expressed in PC12 cells. Neurosci Lett 193, 157-60 (1995). PDF

Publications - 1994                                                         Back to Top


94. Atlas, D. Identifying clonidine-displacing substance. Science 266, 462-4 (1994). PubMed
95. Avidor, B., Avidor, T., Schwartz, L., De Jongh, K.S. & Atlas, D. Cardiac L-type Ca2+ channel triggers transmitter release in PC12 cells. FEBS Lett 342, 209-13 (1994). PubMed
96. Avidor, T., Clementi, E., Schwartz, L. & Atlas, D. Caffeine-induced transmitter release is mediated via ryanodine-sensitive channel. Neurosci Lett 165, 133-6 (1994). PubMed
97.Nuccietelli, R., Ferguson, J. E. Atlas, D. and Kupitz, Y. Fertilization and ion channels. Science 263, 988 (1994) PubMed

Publications - 1993                                                         Back to Top


93. Kupitz, Y. & Atlas, D. A putative ATP-activated Na+ channel involved in sperm-induced fertilization. Science 261, 484-6 (1993). PubMed
91. Ashery, U., Weiss, C., Sela, D., Spira, M.E. & Atlas, D. Membrane depolarization combined with release of calcium from internal stores does not trigger secretion from PC 12 cells. Receptors Channels 1, 217-20 (1993). PubMed
92. Goldberg-Stern, H. et al. Detection and measurement of an endogenous clonidine-displacing substance in human cerebrospinal fluid. Brain Res 601, 325-8 (1993). PubMed

Publications - 1992                                                         Back to Top


85. Atlas, D., Diamant, S. & Zonnenschein, R. Is imidazoline site a unique receptor? A correlation with clonidine-displacing substance activity. Am J Hypertens 5, 83S-90S (1992). PubMed
86. Diamant, S., Eldar-Geva, T. & Atlas, D. Imidazoline binding sites in human placenta: evidence for heterogeneity and a search for physiological function. Br J Pharmacol 106, 101-8 (1992). PubMed
87. Goldberg-Stern, H. et al. Detection and measurement of an endogenous clonidine-displacing-substance (CDS). Neurology 42(1992). N/A Online
88. Osherov, A., Goldberg, D. & Atlas, D. Is the neuronal voltage-sensitive calcium channel of human brain, human pancreatic beta cells and rat brain much larger than predicted by its cDNA sequence? Neurosci Lett 147, 233-5 (1992). PubMed
89. Schwartz, L. & Atlas, D. Potency of depolarization-induced transmitter release is determined by divalent cation influx in PC 12 cells. Neurosci Lett 146, 17-20 (1992). PubMed
90. Schwartz, L., Diamant, S., Barhanin, J. & Atlas, D. Tunicamycin Dissociates Depolarization-induced Calcium Entry From Transmitter Release. Involvement of Glycosylated Protein(s) in the Process of Neurosecretion in PC-12 Cells. Eur J Neurosci 4, 1249-1256 (1992). PubMed

Publications - 1991                                                         Back to Top


80. Atlas, D. Clonidine-displacing substance (CDS) and its putative imidazoline receptor. New leads for further divergence of alpha 2-adrenergic receptor activity. Biochem Pharmacol 41, 1541-9 (1991). PubMed
81. Atlas, D., Diamant, S. & Zonnenchein, R. Imidazoline receptors and the endogenous clonidine displacing substance (CDS). The Pharmacologyof Receptors, 91-100 (1991). N/A Online
82. Sela, D., Ram, E. & Atlas, D. ATP receptor. A putative receptor-operated channel in PC-12 cells. J Biol Chem 266, 17990-4 (1991). PDF
83. Synetos, D., Manolopoulos, V.G., Atlas, D. & Pipili-Synetos, E. Human plasma-derived material with clonidine displacing substance (CDS)-like properties contracts the isolated rat aorta. J Auton Pharmacol 11, 343-51 (1991). PubMed
84. Weiss, C. & Atlas, D. The bradykinin receptor--a putative receptor-operated channel in PC12 cells: studies of neurotransmitter release and inositol phosphate accumulation. Brain Res 543, 102-10 (1991). PubMed

Publications - 1990                                                         Back to Top


73. Atlas, D. The role of calcium in neurotransmitter release: existing models and new approaches to evaluate possible mechanisms. Curr Top Cell Regul 31, 129-59 (1990). PubMed
74. Atlas, D. Clonidine displacing substance (CDS) and its putative imidazoline receptor-new leads for further divergence of alpha2-adrenergic agonists. Biochem Pharmacol 41, 1541-1549 (1990). N/A Online
75. Atlas, D., Diamant, S., Ari, I.L. & Schwartz, L. Possible role for phospholipase C in potentiation of neurotransmitter release in vitro assay for synaptic facilitation. Calcium channel modulators in heart and smooth muscle, 29-41 (1990). N/A Online
76. Coupry, I., Atlas, D., Podevin, R.A., Uzielli, I. & Parini, A. Imidazoline-guanidinium receptive site in renal proximal tubule: asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance. J Pharmacol Exp Ther 252, 293-9 (1990). PubMed
77. Diamant, S., Schwartz, L. & Atlas, D. Potentiation of neurotransmitter release coincides with potentiation of phosphatidyl inositol turnover. A possible in vitro model for long term potentiation. Neurosci Lett 109, 140-5 (1990). PubMed
78. Weiss, C., Sela, D. & Atlas, D. Divalent cations effectively replace Ca2+ and support bradykinin induced noradrenaline release. Neurosci Lett 119, 241-4 (1990). PubMed
79. Zonnenchein, R., Diamant, S. & Atlas, D. Imidazoline receptors in rat liver cells: a novel receptor or a subtype of alpha 2-adrenoceptors? Eur J Pharmacol 190, 203-15 (1990). PubMed

Publications - 1989                                                         Back to Top


67. Ari, I.L., Schwarz, L. & Atlas, D. Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C. Cell Signal 1, 461-70 (1989). PubMed
68. Atlas, D. CDS-Clonidine-displacing substance- a possible neuromodulator of the cardiovascular system. La Lettre du Pharmacologue 3. 3-10 (1989). N/A Online
69. Atlas, D., Diamant, S. & Schwartz, L. Potentiation of neurotransmitter release coincides with potentiation of phosphatidyl inositolnturnover - alpha possible in-vitro model for long-term potentiation. Receptors,Membrane transport and signal transduction 29, 196-213 (1989). N/A Online
70. Diamant, S. & Atlas, D. Potentiation of [3H]inositol phosphate formation by receptor activation and membrane depolarization in brain cortical slices (I). Brain Res 503, 55-61 (1989). PubMed
71. Parini, A. et al. Characterization of an imidazoline/guanidinium receptive site distinct from the alpha 2-adrenergic receptor. J Biol Chem 264, 11874-8 (1989). PDF
72. Schwartz, L. & Atlas, D. Synergy between membrane depolarization and muscarinic receptor activation leads to potentiation of neurotransmitter release (II). Brain Res 503, 62-7 (1989). PubMed

Publications - 1988                                                         Back to Top


65. Diamant, S., Lev-Ari, I., Uzielli, I. & Atlas, D. Muscarinic agonists evoke neurotransmitter release: possible roles for phosphatidyl inositol bisphosphate breakdown products in neuromodulation. J Neurochem 51, 795-802 (1988). PubMed
66. Troen, B.R., Ascherman, D., Atlas, D. & Gottesman, M.M. Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation. J Biol Chem 263, 254-61 (1988). PDF

Publications - 1987                                                         Back to Top


60. Atlas, D., Diamant, S., Fales, H.M. & Pannell, L. The brain's own clonidine: purification and characterization of endogenous clonidine displacing substance from brain. J Cardiovasc Pharmacol 10 Suppl 12, S122-7 (1987). PubMed
61. Bousquet, P., Feldman, J. & Atlas, D. Central cardiovascular effects of a noncatecholamine endogenous ligand for clonidine receptors. J Cardiovasc Pharmacol 10 Suppl 12, S167-71 (1987). PubMed
62. Diamant, S., Avraham, B. & Atlas, D. Neomycin inhibits K+- and veratridine-stimulated noradrenaline release in rat brain slices and rat brain synaptosomes. FEBS Lett 219, 445-50 (1987). PubMed
63. Diamant, S., Eldor, A. & Atlas, D. A low molecular weight brain substance interacts, similarly to clonidine, with alpha 2-adrenoceptors of human platelets. Eur J Pharmacol 144, 247-55 (1987). PubMed
64. Kreisberg, G.A., Diamant, S., Diamant, Y.Z. & Atlas, D. Raised levels of an endogenous nonadrenergic substance in the serum of pregnancy-induced hypertension patients. Isr J Med Sci 23, 1194-7 (1987). PubMed

Publications - 1986                                                         Back to Top


57. Bousquet, P., Feldman, J. & Atlas, D. An endogenous, non-catecholamine clonidine antagonist increases mean arterial blood pressure. Eur J Pharmacol 124, 167-70 (1986). PubMed
58. Diamant, S. & Atlas, D. An endogenous brain substance, CDS (clonidine-displacing-substance), inhibits the twitch response of rat vas deferens. Biochem Biophys Res Commun 134, 184-90 (1986). PubMed
59. Hoffman, S., Jedeikin, R. & Atlas, D. Respiratory monitoring with a new impedance plethysmograph. Anaesthesia 41, 1139-42 (1986). PubMed

Publications - 1985                                                         Back to Top


56. Diamant, S., Agranat, I., Goldblum, A., Cohen, S. & Atlas, D. Beta-adrenergic activity and conformation of the antihypertensive specific alpha 2-agonist drug, guanabenz. Biochem Pharmacol 34, 491-8 (1985). PubMed

Publications - 1984                                                         Back to Top


52. Atlas, D. & Burstein, Y. Isolation and partial purification of a clonidine-displacing endogenous brain substance. Eur J Biochem 144, 287-93 (1984). PubMed
53. Atlas, D. & Burstein, Y. Isolation of an endogenous clonidine-displacing substance from rat brain. FEBS Lett 170, 387-90 (1984). PubMed
54. Kremenetzky, R. & Atlas, D. Solubilization and reconstitution of alpha 2-adrenergic receptors from rat and calf brain. Eur J Biochem 138, 573-7 (1984). PubMed
55. Plotek, Y. & Atlas, D. Is there an overlap between alpha-1-adrenergic receptors and K+ induced Ca 2+ channels? Highlights in Receptor Chemistry (C Melchiorre, ed.), 97-107 (1984). N/A Online

Publications - 1983                                                         Back to Top


49. Hynes, M.D., Atlas, D. & Ruffolo, R.R., Jr. Antinociceptive activity of N-(4-hydroxyphenacetyl)-4-aminoclonidine, a novel analog of clonidine: role of opioid receptors and alpha-adrenoceptors. Pharmacol Biochem Behav 19, 879-82 (1983). PubMed
50. Plotek, Y. & Atlas, D. Characterization of benextramine as an irreversible alpha-adrenergic blocker and as a blocker of potassium-activated calcium channels. Eur J Biochem 133, 539-44 (1983). PubMed
51. Tzivoni, D. et al. Prazosin therapy for refractory variant angina. Am Heart J 105, 262-6 (1983). PubMed

Publications - 1982                                                         Back to Top


44. Atlas, D., Friedman, Z., Litvin, Y. & Steer, M.L. Synthesis of new haloperidol analogues and characterization of their interactions with alpha-adrenoceptors in rat parotid slices and human platelet membranes. Br J Pharmacol 75, 213-7 (1982). PubMed
45. Atlas, D., Plotek, Y. & Miskin, I. An affinity label for alpha 2-adrenergic receptors in rat brain. Eur J Biochem 126, 537-41 (1982). PubMed
46. Atlas, D. & Steer, M.L. Clonidine p-isothiocyanate, an affinity label for alpha 2-adrenergic receptors on human platelets. Proc Natl Acad Sci U S A 79, 1378-82 (1982). PubMed
47. Steer, M.L. & Atlas, D. Demonstration of human platelet beta-adrenergic receptors using 125I-labeled cyanopindolol and 125I-labeled hydroxybenzylpindolol. Biochim Biophys Acta 686, 240-4 (1982). PubMed
48. Steer, M.L. & Atlas, D. Interaction of clonidine and clonidine analogs with human platelet alpha 2-adrenergic receptors. Biochim Biophys Acta 714, 389-94 (1982). PubMed

Publications - 1981                                                         Back to Top


40. Atlas, D. & Adler, M. alpha-adrenergic antagonists as possible calcium channel inhibitors. Proc Natl Acad Sci U S A 78, 1237-41 (1981). PubMed
41. Atlas, D. & Sabol, S.L. Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase. Eur J Biochem 113, 521-9 (1981). PubMed
42. Levitzki, A. & Atlas, D. A possible molecular mechanism for beta-receptor desensitization: experiments and hypotheses. Life Sci 28, 661-72 (1981). PubMed
43. Naor, Z. et al. Interaction of fluorescent gonadotropin-releasing hormone with receptors in cultured pituitary cells. J Biol Chem 256, 3049-52 (1981). PDF

Publications - 1980                                                         Back to Top


38. Atlas, D. & Sabol, S.L. A novel analogue of clonidine with opiate-receptor agonist activity. Biochem Biophys Res Commun 94, 924-31 (1980). PubMed
39. Atlas, D., Volsky, D.J. & Levitzki, A. Lateral mobility of beta-receptors involved in adenylate cyclase activation. Biochim Biophys Acta 597, 64-9 (1980). PubMed

Publications - 1979                                                         Back to Top


37. Atlas, D., Hanski, E. & Levitzki, A. Re-evaluation of the number of specific beta-adrenergic receptors on muscle cells. Nature 277, 58-60 (1979). N/A Online

Publications - 1978                                                         Back to Top


29. Atlas, D. Mapping of beta-adrenergic receptors in the central nervous system, heart and kidney of the rat. Perspectives in Nephrology and HyperTension (1978). N/A Online
30. Atlas, D. & Levitzki, A. Tentative identification of beta-adrenoreceptor subunts. Nature 272, 370-1 (1978). PubMed
31. Atlas, D. & Levitzki, A. Fluorescent visualization of beta-adrenergic receptors on cell surfaces. FEBS Lett 85, 158-62 (1978). PubMed
32. Atlas, D. & Melamed, E. Direct mapping of beta-adrenergic receptors in the rat central nervous system by a novel fluorescent beta-blocker. Brain Res 150, 377-85 (1978). PubMed
33. Atlas, D., Yaffe, D. & Skutelsky, E. Ultrastructural probing of beta-adrenoreceptors on cell surfaces. FEBS Lett 95, 173-6 (1978). PubMed
34. Bloom, S., Atlas, D. & Thompson, J. Heavy water effects on leaky heart muscle cells and actomyosin. Physiol Chem Phys 10, 255-66 (1978). PubMed
35. Lahav, M., Melamed, E., Dafna, Z. & Atlas, D. Localization of beta receptors in the anterior segment of the rat eye by a fluorescent analogue of propranolol. Invest Ophthalmol Vis Sci 17, 645-51 (1978). PubMed
36. Melamed, E., Luhar, M. & Atlas, D. Histochemical labeling of beta-adrenergic receptors in the mouse central nervous system by 9-amino-acridin propranolol. Neurology 28, 850-3 (1978). PubMed

Publications - 1977                                                         Back to Top


20. Atlas, D. beta-Adrenergic receptors. Methods Enzymol 46, 591-601 (1977). PubMed
21. Atlas, D., Hanski, E. & Levitzki, A. Eighty thousand beta-adrenoreceptors in a single cell. Nature 268, 144-6 (1977). PubMed
22. Atlas, D. & Levitzki, A. Probing of beta-adrenergic receptors by novel fluorescent beta-adrenergic blockers. Proc Natl Acad Sci U S A 74, 5290-4 (1977). PubMed
23. Atlas, D., Melamed, E. & Lahav, M. beta-Adrenergic receptors in rat kidney: direct localization by a fluorescent beta-blocker. Lab Invest 36, 465-8 (1977). PubMed
24. Atlas, D. & Schmitt, H. Bromocolchicine as a label for tubulin. Methods Enzymol 46, 567-71 (1977). PubMed
25. Atlas, D. & Segal, M. Simultaneous visualization of noradrenergic fibres and beta-adrenoreceptors in pre- and postsynaptic regions in rat brain. Brain Res 135, 347-50 (1977). PubMed
26. Atlas, D., Teichberg, V.I. & Changeux, J.P. Direct evidence for beta-adrenoreceptors on the Purkinje cells of mouse cerebellum. Brain Res 128, 532-6 (1977). PubMed
27. Melamed, E., Atlas, D. & Lahav, M. Direct evidence for absence of beta-adrenergic receptors in rat cerebral vessels histochemical study with a fluorescent beta-blocker. Stroke 8, 261-3 (1977). PubMed
28. Melamed, E., Lahav, M. & Atlas, D. beta-Adrenergic receptors in rat cerebral cortex: histochemical localization by a fluorescent beta-blocker. Brain Res 128, 379-84 (1977). PubMed

Publications - 1976                                                         Back to Top


13. Atlas, D. & Levitzki, A. An irreversible blocker for the beta-adrenergic receptor. Biochem Biophys Res Commun 69, 397-403 (1976). PubMed
14. Atlas, D., Steer, M.L. & Levitzki, A. Affinity label for beta-adrenergic receptor in turkey erythrocytes. Proc Natl Acad Sci U S A 73, 1921-5 (1976). PubMed
15. Melamed, E., Lahav, M. & Atlas, D. Beta-adrenergic receptors in rat myocardium: direct detection by a new fluorescent beta-blocker. Experientia 32, 1387-9 (1976). PubMed
16. Melamed, E., Lahav, M. & Atlas, D. Histochemical evidence for beta-adrenergic receptors in the rat spinal cord. Brain Res 116, 511-5 (1976). PubMed
17. Melamed, E., Lahav, M. & Atlas, D. Direct localisation of beta-adrenoceptor sites in rat cerebellum by a new fluorescent analogue of propranolol. Nature 261, 420-2 (1976). PubMed
18. Melamed, E., Lahav, M. & Atlas, D. Flourescent evidence for beta-adrenergic receptor in the rat spinal cord. Brain Res. 116, 511-515 (1976). N/A Online PDF
19. Schmitt, H. & Atlas, D. Specific affinity labelling of tubulin with bromocolchicine. J Mol Biol 102, 743-58 (1976). PubMed

Publications - 1975                                                         Back to Top


9. Atlas, D. The active site of porcine elastase. J Mol Biol 93, 39-53 (1975). PubMed
10. Atlas, D., Kalir, R. & Patchornik, A. Synthesis of peptide substrates for porcine elastase via (4-hydroxy-3-nitro)benzylated polystyrene (PHNB). FEBS Lett 58, 179-80 (1975). PubMed
11. Levitzki, A., Sevilia, N., Atlas, D. & Steer, M.L. Ligand specificity and characteristics of the beta-adrenergic receptor in turkey erythrocyte plasma membranes. J Mol Biol 97, 35-46 (1975). PubMed
12. Steer, M.L., Atlas, D. & Levitzki, A. Inter-relations between beta-adrenergic receptors, adenylate cyclase and calcium. N Engl J Med 292, 409-14 (1975). PubMed

Publications - 1974                                                         Back to Top


5. Atlas, D. The active site of pancreatic porcine elastase: Specificity, size and stereospecificity. Israel J. Chem 12, 455-469 (1974). N/A Online
6. Atlas, D. The mapping of the active site of porcine elastase: Size, specificity, stereospecificity and the CPK model. In "Peptides"; Proc. 13th. European Peptide Symposium (Y. Wolman, ed.) Israel Universities Press, Jerusalem, 361 (1974). N/A Online
7. Atlas, D., Steer, M.L. & Levitzki, A. Stereospecific binding of propranolol and catecholamines to the beta-adrenergic receptor. Proc Natl Acad Sci U S A 71, 4246-8 (1974). PubMed
8. Levitzki, A., Atlas, D. & Steer, M.L. The binding characteristics and number of beta-adrenergic receptors on the turkey erythrocyte. Proc Natl Acad Sci U S A 71, 2773-6 (1974). PubMed

Publications - 1973                                                         Back to Top


4. Atlas, D. & Berger, A. Size and stereospecificity of the active site of porcine elastase. Biochemistry 12, 2573-7 (1973). PubMed

Publications - 1972                                                         Back to Top


3. Atlas, D. & Berger, A. On the specificity of elastase. Hydrolysis of peptide p-nitrobenzyl esters. Biochemistry 11, 4719-23 (1972). PubMed

Publications - 1970                                                         Back to Top


1. Atlas, D., Levit, S., Schechter, I. & Berger, A. On the active site of elastase: Partial mapping by means of specific peptide substrates. FEBS Lett 11, 281-283 (1970). PDF
2. Goldstein, L., Pecht, M., Blumberg, S., Atlas, D. & Levin, Y. Water-insoluble enzymes. Synthesis of a new carrier and its utilization for preparation of insoluble derivatives of papain, trypsin, and subtilopeptidase A. Biochemistry 9, 2322-34 (1970). PubMed


Patents                                                                      Back to Top

Process for preparing ethyl ester of L-DOPA. Milman, I., Veinberg, A., Atlas, D. and Melamed, E. United States Patent #5,354,885 11 October (1994) (ref. 95)
Compositions of the ethyl ester of L-DOPA. Milman, I., Veinberg, A., Atlas, D. and Melamed, E. United States Patent #5,525,631 June 11 (1996) (ref. 99)
L-DOPA Ethyl ester to treat Parkinson's (Method of Treatment) Milman, I. Veinberg, A., Atlas, D. and Melamed, E. United States Patent # 5,607,969 4 Mar. 1997. Exp. Date 4 March 2014 (ref. 104)
Pharmaceutical composition of L-DOPA ethyl ester. Cohen, S., Sela, Y., Levy, R., Shterman, N., Melamed, E., and Atlas, D.. United States Patent # 5,840,756 24 Nov. (1998) (ref. 105)
Brain targeted low molecular weight hydrophobic antioxidant compounds. Atlas, D., Melamed, E. and Offen, D. International application WO98/29375 9 July (1998)
Brain targeted low molecular weight hydrophobic antioxidant compounds. Atlas, D., Melamed, E. and Offen, D. United States Patent # US5874468 23 Feb. (1999) (ref. 109)
Compositions of L-Dopa esters. Isaac, M., Veinberg, A., Atlas, D., and Melamed, E. European Patent specification EP 0610595 B1 14 April (1999) (ref. 110)
Treatment of ischemic brain injuries with brain targeted antioxidant compounds Atlas ,D. Melamd,E and Offen D. International application PCTWO 01/47469 5 July 2001. US patent #US6,369,106 B1.
Multi component antioxidants compounds, pharmaceutical compositions containing same and their use for reducing or prevention oxidative stress. Atlas, D. PCT WO 02/34202 A2 May 2002
Multi component antioxidants compounds, pharmaceutical compositions containing same and their use for reducing or prevention oxidative stress. Atlas, D. PCT WO 02/34202 A2 May 2002
Brain targeted low molecular weight hydrophobic antioxidant compounds. Atlas, D., Melamed, E. and Offen, D. Australian Patent #741833 28 March 2002
Brain targeted low molecular weight hydrophobic antioxidant compounds Atlas, D., Melamed, E and Offen D. United States Patent # US 6,420,429 B1 Jul 16 (2002)
Copyright © 2004, The Hebrew University of Jerusalem. All Rights Reserved. Last Updated: October 20, 2004 Webmaster: fitore