Innovative Structural Biology
.jpg "Nature Communications (2020)")
.jpg "PNAS (2021)")
Group Leader: Dr. Nir Kalisman
Department of Biological Chemistry
The Silberman Institute of Life Sciences
The Hebrew University of Jerusalem
Our lab is working to expand the scope of structural biology to macro-molecular systems that are currently
inaccessible. The current focus is on cross-linking and mass-spectrometry (XL-MS), a low-resolution method
that provides rich structural information on nearly any protein complex of interest, regardless of its size,
flexibility, and solubility. We use XL-MS to study very large protein complexes in fields as diverse as
protein-folding, transcription, and neurobiology. The lab also develops computational methods to integrate
XL-MS with Electron Microscopy and Crystallographic data into three-dimensional architectures.
News:
Jun. 29 Congratulations Joanna for your great PhD talk!
May. 18 Congratulations Moriya for your great PhD talk!
Apr. 2 Congratulations Joanna for your Structure paper!