Innovative Structural Biology

Group Leader: Dr. Nir Kalisman
Department of Biological Chemistry
The Silberman Institute of Life Sciences
The Hebrew University of Jerusalem
Our lab is working to expand the scope of structural biology to macro-molecular systems that are currently inaccessible. The current focus is on cross-linking and mass-spectrometry (XL-MS), a low-resolution method that provides rich structural information on nearly any protein complex of interest, regardless of its size, flexibility, and solubility. We use XL-MS to study very large protein complexes in fields as diverse as protein-folding, transcription, and neurobiology. The lab also develops computational methods to integrate XL-MS with Electron Microscopy and Crystallographic data into three-dimensional architectures.

News:

Aug. 5 Congratulations Moriya for the PNAS paper!

Jun. 15 Congratulations Joanna for the JPR paper!